Design, synthesis, and structure-activity relationship of tetrahydropyrido [4,3-d]pyrimidine derivatives as potent smoothened antagonists with in vivo activity

Design, synthesis, and structure-activity relationship of tetrahydropyrido [4,3-d]pyrimidine derivatives as potent smoothened antagonists with in vivo activity
Lu W., Liu Y., Ma H., Zheng J., Tian S., Sun Z., Luo L., Li J., Zhang H., Yang, Z.J.*, Zhang X.* ACS Chemical Neuroscience 8(9):1980-1994 (2017) PMID: 28618224 PDF
(*Co-corresponding Author)