Medulloblastoma and glioblastoma are the two common malignant tumors originating in the central nervous system. In addition, brain metastases occur in approximately 30% of patients with systemic malignancies. Despite significant progress in development of treatments for these tumors, the mortality rate is still high. Moreover, patients often suffer from severe long-term side effects from the aggressive treatment. Our research seeks to elucidate genetic/epigenetic mechanisms underlying brain tumor initiation and progression by using animal models, genomic sequencing as well as high-throughput drug screening, with the aim of translating the findings into improved approaches for the treatment of these devastating diseases.
Our ongoing studies address the following questions:
- How to treat brain tumors by promoting terminal differentiation of tumor cells?
- How cancer cells from extra-cranial malignancies survive and grow in the brain during metastasis?
- How to treat brain tumors by de novo synthesis of cisplatin?
- What are the mechanisms underlying neuronal regeneration after traumatic brain injury?
Principal Investigator
Zeng-jie Yang, M.D. PH.D. is a Professor in Nuclear Dynamics and Cancer Program at Fox Chase Cancer Center in Philadelphia. Dr. Yang research interest focuses on cellular and molecular basis underlying the initiation and progression of brain tumors including primary brain tumors and brain metastasis, and exploration of improved therapeutic strategies for brain tumor treatment.
Research
Lab News
2024 - We are recruiting!
If you are interested in brain tumor research, you are welcome to join us (postdocs) (08/2024). Please send us an email (ude.cccf@gnaY.eijgneZ).
2024 - Welcome Kallie and Natalia!
We are welcoming Katherine Dalton (aka, Kallie) and Natalia Ochoa as our newest lab members. Kallie will be joining the brain metastasis group as a PhD student, and Natalia will be joining the lab as a technician, focusing on differentiation therapy of Medulloblastoma. We are very happy to have you guys!
2024 - Welcome Montserrat!
We are happy to receive Montserrat, a student from the National Autonomous University of Mexico, for a short research stay to help her development as a biomedical research scientist.
Thyroid hormone suppresses medulloblastoma progression through promoting terminal differentiation of tumor cells
Yang Y., Valdes-Rives S.A., Liu Q., Gao T., Burudpakdee C., Li Y., Tan J., Tan Y., Koch C.A., Rong Y., Houser S.R., Wei S., Cai K.Q., Wu J., Cheng SY., Wechsler-Reya R., Yang ZJ. Cancer Cell doi.org/10.1016/j.ccell.2024.07.008 (2024)
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PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating ciliary formation
Zhang, J., Yang, Y.J., Li, X.H., Li, G., Mizukami, T., Liu, Y., Wang, Y., Xu, G.Q., Roder, H., Zhang, L., Yang, Z.J.. Cell Death & Differentiation 10.1038/s41418-023-01131-2 (2023)
PMCID: PMC10154305
PMID: 36813922
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Generating a mouse model for relapsed SHH-group medulloblastoma
Heller, A., Du, F., Liu, Y., Yang, Y., Yang, Z.J.. STAR Protocols doi.org/10.1016/j.xpro.2023.102234 (2023)
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